Effect of Nicotinic Acid on ACTH and Noradrenaline Stimulated Lipolysis in the Rabbit. II. In Vitro Studies Including Comparison with Prostaglandin E1

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Abstract
Perirenal adipose tissue from male rabbits was inrubated in vitro and the glycerol release followed as a measure of lipolysis. Addition of nicotinic acid to the medium did not change the basal release. Nicotinic acid inhibited the noradrenaline stimulated lipolysis only in 3 of 8 rabbits, while PGE, under the same conditions was inhibitory in 6 of 6 rabbits. Nicotinic acid only inhibited lipolysis stimulated by ACTH at low doses in one of seven experiments. In comparison to PGE, nicotinic acid was found to be a weaker inhibitor of lipolysis in rabbit adipose tissue stimulated in various ways in vitro. These findings suggest that the previously seen weak properties of nicotinic acid as a FFA lowering compound in rabbits may be explained by factors within adipose tissue.