Effect of Nicotinic Acid on ACTH and Noradrenaline Stimulated Lipolysis in the Rabbit. I. In Vivo Studies
- 1 June 1970
- journal article
- Published by Wiley in Acta Physiologica Scandinavica
- Vol. 79 (2) , 153-157
- https://doi.org/10.1111/j.1748-1716.1970.tb04715.x
Abstract
ACTH, 50, 10, 2 and 0.5 IU/kg b.w. and noradrenaline, 1.0 μg/kg/min were given i.v. to fed, unanesthetized rabbits either pretreated with nicotinic acid or not.Both ACTH and noradrenaline increased arterial concentration of free fatty acids (FFA). For noradrenaline this effect was present only in rabbits with lower body weight and furthermore the effect was less pronounced and of shorter duration than for ACTH.Nicotinic acid inhibited partly the increase of plasma FFA caused by 0.5 IU of ACTH but not that after the higher doses. Nicotinic acid had sometimes but not always an inhibitory effect on the increase caused by noradrenaline while nicotinic acid by itself did not change the basal levels of plasma FFA.Keywords
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