INFLUENCE OF MASSIVE DOSES OF INSULIN ON PERIPHERAL BLOOD FLOW IN MAN

Publisher Website
Google Scholar
Abstract
The peripheral vascular responses to injs. of massive doses of insulin were studied in a series of patients with schizophrenia by means of the plethysmographic method. A marked increase in blood flow was usually observed in the hand, forearm and leg at the height of the hypoglycemic response. With the termination of hypoglycemia by carbohydrate adm., a rapid decrease in blood flow to below the control level usually occurred, especially in the hand. When glucose was given without the previous inj. of insulin, this marked effect upon blood flow was not apparent. The fallacy of drawing conclusions concerning the metabolism of tissues from data based on arterio-venous differences alone and the necessity for obtaining simultaneous blood flow detns. is stressed.

This publication has 5 references indexed in Scilit: