Strain improvement inStreptomyces galilaeus, a producer of anthracycline antibiotics galirubins
- 1 September 1977
- journal article
- conference paper
- Published by Springer Nature in Folia Microbiologica
- Vol. 22 (5) , 321-328
- https://doi.org/10.1007/bf02877666
Abstract
The production of ε-pyrromycinone glycosides inStreptomyces galilaeus increased 12-fold, with respect to the wild strain, as a result of a sequential procedure including both natural selection and treatment with mutagens (nitrous acid, UV light and γ-irradiation). Nitrous acid exhibited the highest mutagenic effect, both in increasing the productivity and in inducing blocked mutants. A mutant strain blocked in the biosynthesis of glycosides and accumulating free ε-pyrromycinone as the principal metabolite was obtained.Keywords
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