Pilot study of myoblast transfer in the treatment of Becker muscular dystrophy

1 August 1998

journal article
clinical trial
Published by Wolters Kluwer Health in Neurology

Vol. 51 (2) , 589-592
https://doi.org/10.1212/wnl.51.2.589

Abstract

We evaluated myoblast implantation therapy in three subjects with Becker muscular dystrophy who received 60 million myoblasts in one tibialis anterior(TA) muscle 2 months after beginning cyclosporine immunosuppression (5 to 10 mg/kg) that continued for 1 year. Strength of the implanted and control TA muscles was measured before and after treatment using a gauge to record TA contraction force. Our protocol controlled for the effects of cyclosporine and myoblast injections. In this pilot, myoblast implantation did not improve strength of the implanted TA muscles.

Keywords

This publication has 3 references indexed in Scilit:

AAEM minimonograph #47: Normative data in electrodiagnostic medicine
Muscle & Nerve, 1997
Myoblast transfer in duchenne muscular dystrophy
Annals of Neurology, 1993
The Iv International Symposium on Neural Transplantation
Cell Transplantation, 1992