Different Composition of the Eosinophilic Bone Marrow Pool in Reactive Eosinophilia and Eosinophilic Leukaemia

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Abstract
The composition of the eosinophilic cell series in the bone marrow was analyzed in 10 patients with a pronounced reactive eosinophilia (RE) and in 2 with eosinophilic leukemia (EL). An impaired differentiation of eosinophils was found in EL patients compared with the RE group. The ratio of eosinophilic promyelocytes + myelocytes: segmented eosinophils was 9.2 and 9.1, respectively, in the patients with EL and 0.1-3.1 (average 1.3) in RE patients. EL is characterized by an impaired differentiation of eosinophilic bone marrow cells and the recognition of this abnormality is of value in the differential diagnosis between EL and RE.

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