Studies on Radiosensitivity and Biological Properties of Two Tumour Types Indigenous to the Same Host—III

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Abstract
The response of two types of mouse mammary tumour (spindle cell type, faster growing, designated DBAG, and epithelial type, slower growing, designated DBAH, both indigenous to the same host), to a dose of 3000 r applied at 765 r/minute or 7.88 r/minute (ratio 971) was investigated. A significantly greater effect was exerted when both types of tumour were irradiated at the low intensity. This greater effect is demonstrated not only by the relatively greater decrease in the growth rate of the treated tumours, but also by total regression of several of the faster growing DBAG tumours, a result which failed to occur among the tumours irradiated at the high intensity. The dose-rate effect is manifest to a lesser degree in the epithelial type DBAH tumours treated at the low intensity in that no total regressions occurred.

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