The Response of Neoplasms to X-Radiation in Vivo at Increased Oxygen Tension

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Abstract
The response of 2 types of tumor to X-irradiation in vivo at increased oxygen tension was investigated. One of the tumors was an epithelial type, DBAH; the other, a spindle cell type, DBAG. Both tumors were grown by serial transplants in isologous hosts of the inbred DBA/212 strain of mice. A dose of 5000 r applied locally to the spindle cell tumor produced more total regressions in those mice breathing 100% oxygen at 3 atmospheres than in those breathing air. Similar results were obtained with 6000 r applied locally to the epithelial type of tumor. The significance of the results obtained and the implications involved are discussed.