Sex Hormonal Action and Chemical Constitution
- 22 February 1946
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 103 (2669) , 221-223
- https://doi.org/10.1126/science.103.2669.221
Abstract
A substance may be estrogenic if it has a large, rigid and inert molecular structure with 2 active hydrogen bond-forming groups at an optimum distance of 8.55 A. from one another. Trans-p,p ''-dihydroxyazobenzene is an estrogen and shows estrogenic activity when 10-15 mg. are injected subcut. into spayed rats. If the active groups are at a distance of 9-10 A. and have weaker hydrogen bond-forming character, the substance may have androgenic activity. A larger dosage is necessary to produce an androgenic effect than an estrogenic effect.This publication has 9 references indexed in Scilit:
- Synthetic Estrogenic Compounds. I. Monosubstituted Derivatives of 1,3-Di-(p-hydroxyphenyl)-propaneJournal of the American Chemical Society, 1943
- Some Analogs of HexestrolJournal of the American Chemical Society, 1943
- Molecular structure in relation to oestrogenic activity: polynuclear analogues of γ : δ -di-(4-hydroxyphenyl)- n -hexane (‘hexoestrol’)Proceedings of the Royal Society of London. B. Biological Sciences, 1942
- OESTROGENS AND PRO-OESTROGENS RELATED TO STILBENE AND TRIPHENYLETHYLENEJournal of Endocrinology, 1942
- Über neue synthetische, hoch wirksame ÖstrogeneHoppe-Seyler´s Zeitschrift Für Physiologische Chemie, 1942
- Synthetic oestrogenic compounds related to stilbene and diphenylethane. Part IProceedings of the Royal Society of London. B. Biological Sciences, 1939
- 47. Crystal structure and configuration of the isomeric azobenzenesJournal of the Chemical Society, 1939
- Molecular structure in relation to oestrogenic activity. Compounds without a phenanthrene nucleusProceedings of the Royal Society of London. B. Biological Sciences, 1938
- The œstrogenic activity of some condensed-ring compounds in relation to their other biological activitiesProceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character, 1933