Studies on the Efficacy of Diethyxime as an Antidote against Organophosphorus Intoxication in Rats
Open Access
- 1 January 1986
- journal article
- research article
- Published by Elsevier in The Japanese Journal of Pharmacology
- Vol. 41 (3) , 267-271
- https://doi.org/10.1254/jjp.41.267
Abstract
Diethyxime, a non-quaternary cholinesterase reactivator was evaluated for its antidotal efficacy against organophosphorus intoxication in rats using the protection index, cholinesterase reactivation and neuromuscular function as the experimental protocol. Diethyxime along with atropine produced a marked anti-dotal effect against dimethyl dichlorovinyl phosphate (DDVP) poisoning on all the parameters studied. The action of diethyxime was mainly peripheral. The protective efficacy against diisopropyl fluorophosphate (DFP) poisoning was not observed with this reactivator.This publication has 14 references indexed in Scilit:
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