MODE OF INACTIVATION OF INFLUENZA VIRUS BY TANNIC ACID

Publisher Website
Google Scholar
Abstract
The in vivo inhibition of the PR8 strain of influenza virus by tannic acid is a function of duration of incubation and dose of virus injd. If 30 min. are allotted for penetration of as little as 10 LD50 of virus into the chorioallantoic membrane, it invariably reappears in the allantoic cavity despite a temporary delay of 24-36 hrs., which can be attributed to the presence of tannic acid. Once the effect of tannate is overcome, the virus is released into the allantoic fluid at a rate comparable with the control embryos. This phenomenon is not due to acquired resistance but rather to the inactivation of extracellular virus. Intracellular virus did not appear to be influenced.