A new chemical series active against African trypanosomes: benzyltriphenylphosphonium salts
- 1 April 1979
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Medicinal Chemistry
- Vol. 22 (4) , 452-455
- https://doi.org/10.1021/jm00190a019
Abstract
Antitrypanosomal activity for benzyltriphenylphosphonium salts is reported for the first time. Testing was conducted using Trypanosoma rhodesiense infected mice. Of 70 P-containing compounds tested, 21 were active. Sixteen of these active chemical species were benzyltriphenylphosphonium salts. Four were nonbenzyl triphenyl compounds. The remaining active drug was a benzyldiphenylphosphonium salt.This publication has 3 references indexed in Scilit:
- Testing of drugs for antileishmanial activity in golden hamsters infected with Leishmania donovaniInternational Journal for Parasitology, 1977
- In search of anti-Trypanosoma cruzi drugs: new leads from a mouse modelJournal of Medicinal Chemistry, 1977
- Screening Large Numbers of Compounds in a Model Based on Mortality of Trypanosoma Rhodesiense Infected Mice *The American Journal of Tropical Medicine and Hygiene, 1976