Submitochondrial distribution of basic drugs in the isolated perfused lung.
- 1 January 1989
- journal article
- research article
- Published by Pharmaceutical Society of Japan in CHEMICAL & PHARMACEUTICAL BULLETIN
- Vol. 37 (4) , 1109-1111
- https://doi.org/10.1248/cpb.37.1109
Abstract
To clarify the mechanism by which basic drugs accumulate in the lung mitochondria, the binding selectivity of drugs to different submitochondrial components of the perfused rat lung was examined. The accumulation of basic drugs was the highest in the mitochondrial outer membrane fraction. The drug accumulation in this fraction increased with lipid solubility and was dose-dependent. It appears then that selective binding sites for basic drugs are present in the mitochondrial outer membrane.This publication has 5 references indexed in Scilit:
- Accumulation mechanism of basic drugs in the isolated perfused rat lung.CHEMICAL & PHARMACEUTICAL BULLETIN, 1989
- Subcellular Distribution of Basic Drugs Accumulated in the Isolated Perfused LungPharmaceutical Research, 1987
- Binding of Basic Drugs to Rat Lung MitochondriaPharmaceutical Research, 1987
- PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENTJournal of Biological Chemistry, 1951
- A MICROSPECTROPHOTOMETRIC METHOD FOR THE DETERMINATION OF CYTOCHROME OXIDASEJournal of Biological Chemistry, 1951