Efficacy of Unusually High Doses of Tranexamic Acid for the Treatment of Epistaxis in Hereditary Hemorrhagic Telangiectasia

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Abstract
Hereditary hemorrhagic telangiectasia is an autosomal dominant disease characterized by epistaxis, cutaneous telangiectases, and visceral arteriovenous malformations.1 Aminocaproic acid, an antifibrinolytic drug, can reduce epistaxis in hereditary hemorrhagic telangiectasia,2 but its effect is inconsistent.3 We successfully treated three patients who had hereditary hemorrhagic telangiectasia with tranexamic acid, another antifibrinolytic drug.