THE PRODUCTION OF ALIMENTARY GLYCOSURIA BY FORCED FEEDING IN THE RAT

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Abstract
FIFTY-SEVEN YEARS AGO Hofmeister (1889) called attention to the limited ability of the normal animal to assimilate orally-administered carbohydrate, and demonstrated that glucose is excreted in the urine when the assimilation limit is exceeded. The tolerance limits of normal animals to orally-administered carbohydrate, when time is permitted for adaptation to overfeeding, have not been thoroughly studied. In these experiments normal rats were force-fed a high carbohydrate diet with different rates of increment until death. Very large amounts of diet were tolerated by each rat, but after the limit of tolerance was exceeded each rat excreted significant amounts of urinary glucose and developed hyperglycemia following feeding.

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