The Effects of some Anticholinergic Compounds on the Infused Urinary Bladder of Anaesthetized Rabbits

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Abstract
The intravesical pressure and volume of the urinary bladder of anaesthetized rabbits were studied using a urinary bladder infusion technique. It was shown that the anticholinergic compounds used, atropine, emeprone, and PR 197, significantly increased the urinary bladder volume capacity, and that they decreased the micturition pressure. Atropine was the most potent compound in increasing the bladder volume capacity, followed by PR 197 and emeprone, mentioned in order of potency. Atropine and PR 197 increased the bladder volume capacity and the micturition threshold pressure significantly more than emeprone. There was no statistically significant difference between the effects of the different compounds on the residual volume or the micturition pressure. It is suggested that the effects of the compounds are confined mainly to the bladder and most probably to its cholinergic structures.