Drugs and the Newly Born

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Abstract
IN this era of modern specific pharmacology, it is perhaps a truism that any drug active enough to be useful in therapeutics will in overdosage have untoward effects. This margin of safety between useful and dangerous dosage is comfortably large for most proved drugs but has repeatedly been exceeded in the newborn nursery — sometimes blithely, as with oxygen, sometimes willfully, as with vitamin K, sometimes ignorantly, as with chloramphenicol, and always lamentably. In defense of those responsible for these lapses it must be stated that although the principles of pharmacology governing dosage have been known for many years,1 the . . .

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