Radiolabelling of poly(butyl 2‐cyanoacrylate) nanoparticles with a technetium‐99m‐dextran complex

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Abstract
Poly(butyl 2‐cyanoacrylate) nanoparticles have been radiolabelled with a 99mTc‐dextran complex to allow their pattern of biodistribution to be followed by using the technique of gamma scintigraphy. The method involves the preforming of a 99mTc‐dextran complex and using this as a polymerie stabiliser during the formation of nanoparticles. Copolymerisation of this complex with the cyanoacrylate monomer results in the radiolabel being covalently linked to the nanoparticle matrix with a labelling efficiency of approximately 18%. The radiolabelled nanoparticles slowly degrade and release the activity into buffer solution. The release rate was relatively unaffected by the presence of plasma proteins indicating that the system should be suitable for use in vivo.