Studies of Motion Sickness: XVII. Physiological Changes Accompanying Sickness in Man

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Abstract
Men (22) were stimulated in an elevator-like apparatus for 1 hour or until they vomited, whichever occurred first. Simultaneous measures of a number of physiological variables were obtained. The vomiting group could be distinguished from the not-sick group by the following differences: (a) greater increase in pulse rate, (b) greater vasoconstriction, (c) greater increment in ventilation, (d) more abrupt decrement in gastric tone, (e) more sweating and (f) more facial pallor. With the exception of pallor, these differences were evident only in the comparison of group means because of the great between- and within-subject variability. The only common sequence of events, true of most individuals, was the onset of pallor, then the report of nausea and finally vomiting. All other variables showed considerable individual variation.

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