Basophilenaktivierungstests in der Diagnostik von Arzneimittelreaktionen
- 1 January 2005
- journal article
- abstracts
- Published by Springer Nature in Die Dermatologie
- Vol. 56 (1) , 38-43
- https://doi.org/10.1007/s00105-004-0871-8
Abstract
Over the past 10 years a number of studies on basophil activation tests (BAT) have been published which focus on their use as diagnostic methods in clarifying IgE-mediated hypersensitivity reactions to various allergens including drugs. These BAT are based on flow cytometric quantification of allergen- induced CD63 or CD203 expression or measurement of sulfo leukotriene release by ELISA. In the diagnosis of penicillin allergy, the combined use of the CD63-BAT and specific IgE increases sensitivity. The role of BAT in the diagnosis of non-IgE-mediated reactions to non-steroidal anti- inflammatory drugs remains to be clarified. This article focuses on (1) the principles of BAT, (2) technical aspects, (3) clinical applications and (4) recommendations for further development.Keywords
This publication has 26 references indexed in Scilit:
- Regarding Ebo DG, Hagendorens MM, Bridts CH, Schuerwegh AJ, De Clerck LS & Stevens WJ. In vitro allergy diagnosis: should we follow the flow? Clin Exp Allergy 2004; 34:332–9Clinical and Experimental Allergy, 2004
- IntoleranzreaktionenDeutsche Medizinische Wochenschrift (1946), 2003
- About science and politicsDeutsche Medizinische Wochenschrift (1946), 2003
- BasotestR and suxamethonium all_ergyAllergy, 2001
- IgE-mediated anaphylaxis after first intravenous infusion of cyclosporineAnnals of Allergy, Asthma & Immunology, 2001
- Anaphylaxis to starchAllergy, 2000
- Increased in vitro cvsteinvl leukotriene release from blood leukocytes in patients with asthma, nasal polyps, and aspirin intoleranceAllergy, 1996
- Release of sulfidoleukotrienes in vitro: Its relevance in the diagnosis of pseudoallergy to acetylsalicylic acidInflammation Research, 1995
- The effect of interleukin 3 upon IgE‐dependent and IgE‐independent basophil degranulation and leukotriene generationEuropean Journal of Immunology, 1991
- A monoclonal antibody against the sulfidopeptide leukotrienes LTC4, LTD4 and LTE4Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1991