Endogenous Pyrogen Release from Rabbit Blood Cells Incubated in vitro with Parainfluenza Virus
- 11 December 1964
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 146 (3650) , 1469-1470
- https://doi.org/10.1126/science.146.3650.1469
Abstract
Rabbit blood cells incubated in vitro with purified parainfluenza-5 virus (DA strain) released a rapidly acting pyrogen. Spleen and lymph node cells were inactive. The pyrogen resembled in behavior a pyrogen extracted from granulocytic exudates. Similar cells in the blood are believed to be activated by virus in vivo to produce the circulating endogenous pyrogen that mediates virus-induced fever.Keywords
This publication has 9 references indexed in Scilit:
- STUDIES ON THE PATHOGENESIS OF FEVERThe Journal of Experimental Medicine, 1964
- PATHOGENESIS OF FEVER IN RABBITS FOLLOWING INTRAVENOUS INJECTION OF COXSACKIE VIRUS1964
- STUDIES IN STAPHYLOCOCCAL FEVER .1. RESPONSES TO BACTERIAL CELLS1963
- Studies of a Myxovirus Isolated from Human BloodThe Journal of Immunology, 1962
- STUDIES ON THE PATHOGENESIS OF FEVERThe Journal of Experimental Medicine, 1962
- OBSERVATIONS ON THE PRODUCTION OF PYROGENIC SUBSTANCES BY RABBIT AND HUMAN LEUCOCYTESThe Journal of Experimental Medicine, 1961
- ENDOTOXIN FEVER IN GRANULOCYTOPENIC ANIMALSThe Journal of Experimental Medicine, 1961
- STUDIES ON THE PATHOGENESIS OF FEVERThe Journal of Experimental Medicine, 1959
- STUDIES ON THE PATHOGENESIS OF FEVER WITH INFLUENZAL VIRUSESThe Journal of Experimental Medicine, 1958