H-2L: Demonstration of Four New Allelic Products and Independence of H-2D and H-2L Molecules

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Abstract
Mouse H-2L (major histocompatibility complex) molecules were detected for the first time in Dd region products using antisera against the public specificity H-2.28. This specificity was analyzed because its presence in K and in D region products and its apparent allelism with another public specificity, H-2.1, indicated that these 2 specificities may have a special position in the H-2 system. This was corroborated by subsequent identification of H-2L molecules in Dq and Dk products using anti-H-2.28 and anti-H-2.1 sera, respectively, while none of the other previously known public or private specificities was detected on H-2L molecules. The products of 4 D region alleles which had not been analyzed previously were tested. In each of them 2 distinct types of molecules were identified: H-2D, which reacts with sera against the D region private specificity, and H-2L, which does not react with these sera, but which is detectable either by anti-H-2.28 sera (H-2Lb, H-2Lf, H-2Ls) or by anti-H-2.1 sera (H-2Ldx). This increases the number of identified H-2L alleles to 7 (5 H-2.8+, 2 H-2.1+). No association between H-2D and H-2L molecules on the cell surface was detected in capping experiments.