Orientation of Caffeine within the Active Site of Human Cytochrome P450 1A2 Based on NMR Longitudinal (T1) Relaxation Measurements
- 1 December 2000
- journal article
- Published by Elsevier in Archives of Biochemistry and Biophysics
- Vol. 384 (1) , 47-58
- https://doi.org/10.1006/abbi.2000.2073
Abstract
No abstract availableKeywords
This publication has 48 references indexed in Scilit:
- The Substrate Binding Site of Human Liver Cytochrome P450 2C9: An NMR StudyBiochemistry, 1997
- Expression of human cytochrome P4501A1 (CYP1A1) in Saccharomyces cerevisiae inhibits cell divisionXenobiotica, 1996
- 1H NMR T1 relaxation rate study on substrate orientation of fluoromethylanilines in the active sites of microsomal and purified cytochromes P450 1A1 and 2B1FEBS Letters, 1995
- Three-dimensional models of human and other mammalian microsomal P450s constructed from an alignment with P450102 (P450bm3)Xenobiotica, 1995
- Deuterium Isotope Effects on A-Ring and D-Ring Metabolism of Testosterone by CYP2C11: Evidence for Dissociation of Activated Enzyme-Substrate ComplexesBiochemistry, 1994
- Molecular Modeling of Enzymes and Receptors Involved in Carcinogenesis: Qsars and Compacted-3DDrug Metabolism Reviews, 1994
- Substrate mobility in thiocamphor-bound cytochrome P450cam: an explanation of the conflict between the observed product profile and the X-ray structureProtein Engineering, Design and Selection, 1993
- Proton NMR of the interaction of benzo(a)pyrene with rat liver microsomal cytochrome P‐450FEBS Letters, 1992
- Electron spin resonance studies of wild-type and mutant cytochromes P-450d: effects of mutations at proximal, aromatic and distal sites on g valuesBiochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology, 1990
- Relationship between paracetamol binding to and its oxidation by two cytochromes P-450 isozymes—a proton nuclear magnetic resonance and spectrophotometric studyXenobiotica, 1987