Silymarin inhibits TNF‐α‐induced expression of adhesion molecules in human umbilical vein endothelial cells
- 30 July 2003
- journal article
- Published by Wiley in FEBS Letters
- Vol. 550 (1-3) , 89-93
- https://doi.org/10.1016/s0014-5793(03)00827-5
Abstract
Silymarin is known to have an anti‐atherosclerotic activity, but the mechanism responsible for it remains unclear. Here, we demonstrate a possible mechanism involved in the anti‐atherosclerotic activity of silymarin. Silymarin inhibited THP‐1 cell adhesion to human umbilical vein endothelial cells (HUVECs). Silymarin also suppressed the TNF‐α‐induced protein and mRNA expression of adhesion molecules, such as VCAM‐1, ICAM‐1 and E‐selectin, in HUVECs. Moreover, silymarin suppressed the TNF‐α‐induced DNA binding of NF‐κB/Rel in HUVECs. Taken together, these results demonstrate that silymarin exerts an anti‐atherosclerotic activity, at least in part, by inhibiting the expression of adhesion molecules.Keywords
This publication has 29 references indexed in Scilit:
- Arterial Inflammation and AtherosclerosisTrends in Cardiovascular Medicine, 2002
- AtherosclerosisCell, 2001
- Inhibitory Effect of Flavonoids on Low-Density Lipoprotein Peroxidation Catalyzed by Mammalian 15-LipoxygenaseIUBMB Life, 2000
- Curcuma longa inhibits TNF-α induced expression of adhesion molecules on human umbilical vein endothelial cellsInternational Journal of Immunopharmacology, 1999
- Tissue distribution of silibinin, the major active constituent of silymarin, in mice and its association with enhancement of phase II enzymes: implications in cancer chemopreventionCarcinogenesis: Integrative Cancer Research, 1999
- Selective inhibition of NF‐κB activation by the flavonoid hepatoprotector silymarin in HepG2FEBS Letters, 1998
- The combined role of P- and E-selectins in atherosclerosis.Journal of Clinical Investigation, 1998
- NF-κB AND REL PROTEINS: Evolutionarily Conserved Mediators of Immune ResponsesAnnual Review of Immunology, 1998
- Selective Inhibition of Tumor Necrosis Factor–Induced Vascular Cell Adhesion Molecule-1 Gene Expression by a Novel FlavonoidArteriosclerosis, Thrombosis, and Vascular Biology, 1996
- The expression of the adhesion molecules ICAM‐1, VCAM‐1, PECAM, and E‐selectin in human atherosclerosisThe Journal of Pathology, 1993