Indirect Determination of Lidocaine by Atomic Absorption Spectrophotometry

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Abstract
A new procedure for determining lidocaine chlorhydrate is described. The method consists of extracting an ion pair composed of Lidocaine and the inorganic complex Co(SCN)4 2- into an organic solvent (1, 2 dichloroethane), then measure the Co in the organic phase by A.A.S. at 240.7 mm. Optimal experimental conditions concerning pH, Co(SCN)4 −2 concentration, shaking time, phase ratio, number of extractions and linear range for calibration are studied. The method has a standard deviation of 10−2. Two pharmaceutical preparations containing lidocaine, have been analyzed with very good results.