LEVELS OF 2'-DEOXYCOFORMYCIN, ADENOSINE, AND DEOXYADENOSINE IN PATIENTS WITH ACUTE LYMPHOBLASTIC-LEUKEMIA
- 1 January 1981
- journal article
- research article
- Vol. 41 (11) , 4508-4511
Abstract
2''-Deoxycoformycin (dCF), a potent inhibitor of adenosine deaminase, has recently undergone phase I clinical trials and was found to be therapeutically active in acute lymphoblastic leukemia. In this report, levels of dCF in plasma, plasma concentrations of adenosine and deoxyadenosine and urine levels of deoxyadenosine were measured in leukemic patients undergoing treatment with dCF during a phase I clinical trial. dCF was administered i.v. at a dose of 0.25-1.0 mg/kg (7.5-30 mg/sq m) for 3 consecutive days. Plasma drug levels of 2 to 6 .mu.M were observed following the 3rd dose of dCF, and drug accumulation occurred only at the 1-mg/kg dosage. In this limited series of patients the plasma concentrations of adenosine and deoxyadenosine and the urine concentration of deoxyadenosine did not show an obvious correlation with dCF dose, therapeutic response or toxicity.This publication has 11 references indexed in Scilit:
- ATP depletion as a consequence of adenosine deaminase inhibition in man.Proceedings of the National Academy of Sciences, 1980
- Animal model for immune dysfunction associated with adenosine deaminase deficiency.Proceedings of the National Academy of Sciences, 1980
- REMISSION INDUCTION WITH ADENOSINE-DEAMINASE INHIBITOR 2'-DEOXYCOFORMYCIN IN THY-LYMPHOBLASTIC LEUKÆMIAThe Lancet, 1980
- INHIBITION OF ADENOSINE-DEAMINASE ACTIVITY RESULTS IN CYTO-TOXICITY TO T-LYMPHOBLASTS INVIVO1980
- In vivo inhibition of adenosine deaminase by 2'-deoxycoformycin in mouse blood and leukemia L1210 cellsBiochemical Pharmacology, 1980
- Adenylate deaminase: Potent inhibition by 2′-deoxycoformycin 5′-phosphateBiochemical and Biophysical Research Communications, 1979
- Enzyme inhibition titration assay for 2′-deoxycoformycin and its application to the study of the relationship between drug concentration and tissue adenosine deaminase in dogs and ratsBiochemical Pharmacology, 1979
- TREATMENT OF ACUTE LYMPHOBLASTIC-LEUKEMIA WITH 2'-DEOXYCOFORMYCIN - CLINICAL AND BIOCHEMICAL CONSEQUENCES OF ADENOSINE-DEAMINASE INHIBITION1979
- Tight-binding inhibitors—IV. Inhibition of adenosine deaminases by various inhibitorsBiochemical Pharmacology, 1977
- Enhancement of the biological activity of cordycepin (3'-deoxyadenosine) by the adenosine deaminase inhibitor 2'-deoxycoformycinBiochemical Pharmacology, 1976