SIGNIFICANCE OF STIMULATION IN LEUKOCYTE MIGRATION TEST AS AN INDICATOR OF CELLULAR-HYPERSENSITIVITY - STUDIES USING TAMM-HORSFALL GLYCOPROTEIN AS ANTIGEN

  • 1 January 1978
    • journal article
    • research article
    • Vol. 31  (2) , 174-177
Abstract
To determine whether stimulation of [human] leukocyte migration in the presence of an antigen is a reliable indicator of sensitization, the results of leukocyte migration using a kidney antigen (Tamm-Horsfall glycoprotein) were compared with those of lymphocyte transformation using the same antigen and with lymphocyte cytotoxicity for cells known to synthesize this antigen. There was a close correlation between the results of all 3 tests. The stimulation of leukocyte migration as an immunological phenomenon is probably as valid as migration inhibition in demonstrating sensitization.