THE EFFECTS OF GRADED DOSAGES OF ESTROGEN UPON PITUITARY CYTOLOGY AND FUNCTION1

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Abstract
Histological studies and gonadotrophic assays were made of the pituitary glands of immature ovariectomized rats which had been injd. with graded amts. of dienestrol (0.025-5 [mu]g./day) for a period of 10 days. The high pituitary gonadotrophic content of castration was not changed significantly by low estrogen injn. (0.1 [mu]g. dienestrol/day). The percentage of basophile cells was decreased in direct proportion to the concn. of estrogen. Acidophilic cells were increased in percentage by the lower doses reaching a peak of 47.4% at O.10 [mu]g. dienestrol per day, and decreased by the highest doses to 31.2%, compared to 39.1% in the uninjd. ovariectomized controls. Dienestrol exerts effects upon the structure and function of the hypophysis similar to those of estradiol and diethylstilbestrol.