Ph2SO/Tf2O: a Powerful Promotor System in Chemoselective Glycosylations Using Thioglycosides
- 5 April 2003
- journal article
- letter
- Published by American Chemical Society (ACS) in Organic Letters
- Vol. 5 (9) , 1519-1522
- https://doi.org/10.1021/ol034312t
Abstract
Diphenylsulfoxide in combination with triflic anhydride provides a very potent thiophilic glycosylation promotor system, capable of activating disarmed thioglycosides. The usefulness of this novel thiophilic activator is illustrated in a successful chemoselective glycosylation sequence in which the donor thioglycoside in the first condensation step may be either armed or disarmed.Keywords
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