METABOLIC-ACTIVATION OF VINYL-CHLORIDE AND VINYL BROMIDE BY ISOLATED HEPATOCYTES AND HEPATIC SINUSOIDAL CELLS
- 1 January 1980
- journal article
- research article
- Vol. 4 (1) , 411-417
Abstract
The formation of liver sinusoidal cell tumors after exposure to vinyl chloride led to a survey of hepatocytes and sinusoidal cells isolated from rat liver as to their ability to metabolically activate vinyl chloride and vinyl bromide. Metabolism of these vinyl halides to reactive metabolites is confined primarily to hepatocytes. This favors the theory that in the liver reactive metabolites of vinyl chloride leave the hepatocytes to act on hepatic sinusoidal cells.This publication has 5 references indexed in Scilit:
- Vinyl chloride and trichloroethylene: Comparison of alkylating effects of metabolites and induction of preneoplastic enzyme deficiencies in rat liverZeitschrift für Krebsforschung und Klinische Onkologie, 1979
- Pharmacokinetics of halogenated ethylenes in ratsArchives of Toxicology, 1978
- RAT HEPATOCYTES AND SINUSOIDAL CELLS - SIMULTANEOUS ISOLATION AND ACTIVITY OF UREA CYCLE ENZYMES1977
- Liver microsomal uptake of 614C9vinyl chloride and transformation to protein alkylating metabolites in vitroToxicology and Applied Pharmacology, 1976
- CONTROL OF LEVELS OF FREE AMINO ACIDS IN PLASMA BY LIVER1965