An Evaluation of Ultrafiltration as Treatment of Diuretic‐resistant Oedema in Nephrotic Syndrome

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Abstract
Plasma volume, plasma colloid osmotic pressure, creatinine clearance and Na excretion were measured before and after ultrafiltration treatment in 6 patients with diuretic-resistant nephrotic syndrome. The mean total ultrafiltrate volume in 2 sessions on 2 successive days was 7460 ml, the mean ultrafiltration rate was 22.0 ml/min and the calculated plasma refilling rate was 19.9 ml/min. Plasma volume and creatinine clearance were unchanged and Na excretion was reduced after treatment. A short-lasting drop in blood pressure was seen in 3 of the 12 treatment sessions. No other complications were noted. Ultrafiltration is a safe and useful alternative in the treatment of the few patients with massive edema due to nephrotic syndrome not responding to conventional therapy.

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