Transvascular osmotic flow reflected by changes in plasma oncotic pressure of anesthetized dog.

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Abstract
To assess overall bodily transvascular fluid flow due to osmotic imbalance between blood and interstitial fluid during or after addition of hypertonic saline, sugar, albumin and dextran solutions or CO2 mixture to blood, arterial blood colloid osmotic pressure (COP) of anesthetized dogs was continuously measured with a needle-type colloid osmometer. Plasma volume change (.DELTA.Vp) was estimated from the changes in either the equivalent albumin concentration (C) or the albumin concentration equivalent to plasma COP, which was well confirmed in inanimate model experiments. CO2 inhalation caused RBC [red blood cell] swelling (1.5% volume increase/10 mmHg of PCO2). I.v. injection of hypertonic solutions resulted in transient osmotic flow (8.5 .+-. 2.2 ml/g solute per kg animal weight by NaCl, and 1.7 .+-. 0.4 by glucose). Albumin and dextran induced fluid flow (1.3 .+-. 0.4 by albumin and 2.2 .+-. 0.7 by dextran), which depended on van''t Hoff''s law and reflection coefficient of solutes.