Synthesis of α‐2′‐deoxynucleosides

Abstract
α‐Thymidine (4) was synthesized from thymidine (1) in 3 steps in 36% overall yield without using chro‐matography and with the possibility of increasing the yield to 85% by reusing the remaining α,β‐mixture. 1‐(2‐Deoxy‐3,5‐di‐O‐p‐toluoyl‐α‐D‐erythro‐pentofuranosyl)thymine (3) was further converted to 1‐(2‐deoxy‐α‐D‐erythro‐pentofuranosyl)‐5‐methylcytosine (5).

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