Synthesis of α‐2′‐deoxynucleosides
- 1 September 1995
- journal article
- research article
- Published by Wiley in Journal of Heterocyclic Chemistry
- Vol. 32 (5) , 1645-1646
- https://doi.org/10.1002/jhet.5570320542
Abstract
α‐Thymidine (4) was synthesized from thymidine (1) in 3 steps in 36% overall yield without using chro‐matography and with the possibility of increasing the yield to 85% by reusing the remaining α,β‐mixture. 1‐(2‐Deoxy‐3,5‐di‐O‐p‐toluoyl‐α‐D‐erythro‐pentofuranosyl)thymine (3) was further converted to 1‐(2‐deoxy‐α‐D‐erythro‐pentofuranosyl)‐5‐methylcytosine (5).Keywords
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