Oligoclonal gamma-globulin of cerebrospinal fluid in neurobrucellosis

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Abstract
The clinical manifestations and laboratory findings of two cases of neurobrucellosis are described. The cerebrospinal fluid (CSF) protein electro‐phoresis showed increased gamma‐globulins and decreased relative values of pre‐albumin and albumin, associated to high values of total CSF protein. The evidence of oligoclonal morphology of CSF gamma‐globulins suggests that part of them had an intrathecal origin, in addition to an increased crossing of the damaged blood‐CSF barrier. Similar oligoclonal appearance of CSF gamma‐globulins was observed in two additional cases of neurobrucellosis previously reported.