Quinine-induced agranulocytosis: toxic effect of quinine bisulphate on bone marrow cultures in vitro.
- 5 March 1977
- Vol. 1 (6061) , 605-607
- https://doi.org/10.1136/bmj.1.6061.605
Abstract
In a case of quinine-induced agranulocytosis marrow culture studies confirmed the inhibitory effect on the patient's cells of equivalent therapeutic plasma concentrations of quinine. Similar concentrations had no effect on normal marrow cells. Quinidine, the stereoisomer of quinine, had no effect on either cells from the patient or normal cells. The results encourage the use of in-vitro bone marrow cultures for identifying drugs responsible for agranulocytosis.Keywords
This publication has 3 references indexed in Scilit:
- The Effects of Drugs that Cause Neutropenia upon Colony Formation by Bone Marrow Cells in Semi-Solid AgarClinical Science, 1974
- Effect of Chloramphenicol and Thiamphenicol on the In Vitro Colony-forming CellBlood, 1974
- Amodiaquine-induced Agranulocytosis: Toxic Effect of Amodiaquine in Bone Marrow Cultures In VitroBMJ, 1973