Chemical mutagenesis testing in Drosophila. II. Results of 20 coded compounds tested for the national toxicology program
- 1 January 1985
- journal article
- research article
- Published by Wiley in Environmental Mutagenesis
- Vol. 7 (1) , 87-100
- https://doi.org/10.1002/em.2860070105
Abstract
Results are presented from mutagenesis testing in Drosophila of 20 coded compounds. Two compounds were positive in the sex‐linked recessive lethal test, and two were inconclusive. The positive compounds were calcium chromate in adult feeding experiments and ferrocene after adult injection. The two inconclusive compounds were 2,4‐diaminophenol dihydrochloride and hexachiorocyclopentadiene. Compounds that produced a positive response were assayed for chromosome breakage using the conventional translocation test. Calcium chromate was negative in the translocation test, and ferrocene was positive. Many of the test compounds were poorly soluble in water, raising questions regarding the effective concentration to which the flies were exposed.Keywords
This publication has 7 references indexed in Scilit:
- Mutagenic effects of chlorinated phenoxyacetic acids in Drosophila melanogasterHereditas, 2009
- Chemical mutagenesis testing in Drosophila: I. Comparison of positive and negative control data for sex‐linked recessive lethal mutations and reciprocal translocations in three laboratoriesEnvironmental Mutagenesis, 1983
- The mei‐9a test for chromosome loss in drosophila: A review of assays of 21 chemicals for chromosome breakageEnvironmental Mutagenesis, 1983
- Statistical analysis and sample‐size determinations for mutagenicity experiments with binomial responsesEnvironmental Mutagenesis, 1983
- Studies on the induction of sex-linked recessive lethal mutations in Drosophila melanogaster by nitroheterocyclic compoundsMutation Research/Genetic Toxicology, 1982
- Mutagenicity testing of cyclamate and some pesticides inDrosophila melanogasterCellular and Molecular Life Sciences, 1974
- MUTATION TEST OF 2,4,5-TRICHLOROPHENOXYACETIC ACID ON DROSOPHILA MELANOGASTERCanadian Journal of Genetics and Cytology, 1974