Supplemental administration of 1α-hydroxyvitamin D3 inhibits promotion by intrarectal instillation of lithocholic acid in N-methyl-N-nitrosourea-induced colonic tumorigenesis in rats

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Abstract
The effect of 1α-hydroxyvitamin D3 [1α(OH)D3) on promotion by intrarectal instillation of lithocholic acid (LC) in N-methyl-N-nitrosourea (MNU)-induced colonic tumorigenesis was studied in a rodent model. Ninety-two female F344 rats received intrarectal injection of 2.5 mg of MNU twice in one week followed by 1 mg of LC or its vehicle alone three times weekly for 48 weeks. Those which received LC were given a concomitant intragastric administration of 0.04 μg of 1α(OH)D3 or its vehicle alone three times weekly. In the group receiving MNU alone (n=30) five rats bore colomc tumors; in the MNU + LC group (n=32) 15 and in the MNU + LC + 1α(OH)D3 group (n=30) six rats bore colonic tumors (MNU + LC versus MNU + LC + 1α(OH)D3 group, P3.