Synthesis of poly(propylene fumarate)
- 26 March 2009
- journal article
- research article
- Published by Springer Nature in Nature Protocols
- Vol. 4 (4) , 518-525
- https://doi.org/10.1038/nprot.2009.24
Abstract
This protocol describes the synthesis of 500–4,000 Da poly(propylene fumarate) (PPF) by a two-step reaction of diethyl fumarate and propylene glycol through a bis(hydroxypropyl) fumarate diester intermediate. Purified PPF can be covalently cross-linked to form degradable polymer networks, which have been widely explored for biomedical applications. The properties of cross-linked PPF networks depend upon the molecular properties of the constituent polymer, such as the molecular weight. The purity of the reactants and the exclusion of water from the reaction system are of utmost importance in the generation of high-molecular-weight PPF products. Additionally, the reaction time and temperature influence the molecular weight of the PPF product. The expected time required to complete this protocol is 3 d.Keywords
This publication has 57 references indexed in Scilit:
- Biodegradable fumarate‐based drug‐delivery systems for ophthalmic applicationsJournal of Biomedical Materials Research Part A, 2008
- In vitro cytotoxicity of single‐walled carbon nanotube/biodegradable polymer nanocompositesJournal of Biomedical Materials Research Part A, 2007
- Fabrication of porous ultra-short single-walled carbon nanotube nanocomposite scaffolds for bone tissue engineeringBiomaterials, 2007
- Long-term release of fluocinolone acetonide using biodegradable fumarate-based polymersJournal of Controlled Release, 2006
- Methods: A Comparative Analysis of Radiography, Microcomputed Tomography, and Histology for Bone Tissue EngineeringTissue Engineering, 2005
- Poly(lactide) Stereocomplexes: Formation, Structure, Properties, Degradation, and ApplicationsMacromolecular Bioscience, 2005
- Effect of biomaterial properties on bone healing in a rabbit tooth extraction socket modelJournal of Biomedical Materials Research Part A, 2003
- Three‐dimensional culture of differentiating marrow stromal osteoblasts in biomimetic poly(propylene fumarate‐co‐ethylene glycol)‐based macroporous hydrogelsJournal of Biomedical Materials Research Part A, 2003
- Photoinitiated Cross-Linking of the Biodegradable Polyester Poly(propylene fumarate). Part I. Determination of Network StructureBiomacromolecules, 2003
- Adhesion and migration of marrow‐derived osteoblasts on injectablein situcrosslinkable poly(propylene fumarate‐co‐ethylene glycol)‐based hydrogels with a covalently linked RGDS peptideJournal of Biomedical Materials Research Part A, 2003