The regulation of pregnancy-associated murine protein 1 by gonadal steroids

Abstract
Pregnancy-asssociated murine protein 1 (PAMP-1) was present in the circulation of all mice at 1-day of age but not at days 2-20. PAMP-1 values were low in juvenile male mice during puberty but reached normal adult female levels within 35 days of birth in females. Concentrations in castrated males were similar to those of non-pregnant females within 6 wk of operation. Testosterone treatment of castrated males and sexually mature females, as well as ovariectomy of adult females resulted in a significant fall in PAMP-1 concentrations. PAMP-1 is apparently sex-steroid dependent.