Varicella-zoster infections in pregnancy

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Abstract
Ten pregnant women with varicella and one women with herpes zoster were studied. Only one of these women had a complicated course characterized by nephritis and hepatitis and the birth of a stillborn infant. One other woman who had vaginal bleeding for a month prior to the onset of varicella aborted 2 weeks after recovery from varicella. Seven women who were observed to term delivered normal, full-term infants. Large doses of gamma -globulin which were given to 4 infants whose mothers had varicella within a week prior to delivery failed to produce a detectable rise in serum varicella-zoster (V-Z) antibodies. Three of these infants who were born without V-Z serum antibody got neonatal varicella. All recovered uneventfully.

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