THE URINARY EXCRETION OF CHORIONIC GONADOTROPIN BY HUMAN FEMALES FOLLOWING PARENTERAL ADMINISTRATION OF AQUEOUS OR BEESWAX SOLUTIONS

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Abstract
A comparison was made of the persistence of chorionic gonadotropin in the urine of normal women after injn. with aqueous and with beeswax-in-oil solns. of chorionic gonadotropin. A slightly longer duration of excretion of gonadotropic material was detectable following injn. of the beeswax soln. as compared with the aqueous soln. The beeswax soln. injn. was followed by a longer interval before appearance of the gonadotropin in the urine, suggesting a slower rate of absorption. Local systemic reactions were frequent following beeswax injn.; no reactions followed aqueous soln. injn. No change in plasma vitamin C level occurred following injn. of chorionic gonadotropin. Excretion of gonadotropin by pregnant women can be increased by parenteral admin. of chorionic gonadotropin.

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