Tumor Incidence in Mice After Oral Painting With Cigarette Smoke Condensate

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Abstract
The effect of oral painting with cigarette tobacco tar on the incidence of pulmonary tumors in Swiss mice was studied. Compared to the control mice, at 18 to 19 months of age the animals treated with whole tar, heptane, and residue fractions had more than double the incidence of pulmonary tumors and over three times the number of other tumors, chiefly of the leukemia-lymphoma group. The pulmonary tumors were predominantly adenomas, but there were a few papillary adenocarcinomas and one anaplastic carcinoma. Although not strictly comparable, the tar concentrations in whole tar, heptane, and residue fractions produced significant increases in the incidence of pulmonary tumors (64.2, 59.3, and 46.5%, respectively), as compared with untreated controls (22.3%).