Carcinogenic Activity of Cigarette-Smoke Condensate. I. Effect of Trauma and Remote X Irradiation2

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Abstract
In Swiss mice painted with cigarette-smoke condensate, benign and malignant skin tumors were produced in all groups, regardless of coincident irritation. The data indicate that qualitative differences in laboratory results probably are not due to minor differences in skin-painting techniques but may be due to differences in mouse stocks employed. In Swiss female and C3H male mice, intense irradiation of a small area increased the sensitivity of distant areas of skin to painting with cigarette-smoke condensate. In this case, X irradiation apparently acted as a systemic initiating agent of carcinogenesis. The Swiss female mice were much more sensitive to the combined treatment than were the C3H males.