Characteristics of Apparent Derivatives of the 2512 Strain of Infectious Bursal Disease Virus When Used as Vaccines

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Abstract
The 2512 infectious bursal disease virus (IBDV) strain was compared with apparent 2512 IBDV isolates designated I-2512, P-2512 and H-2512. The latter 3 viruses were obtained from different sources and, ostensibly, had their origin in the same laboratory [Purdue University, Indiana, USA]. Their effects on immunogenicity, transmissibility, pathogenicity and [chicken] cell cultures varied. One of these isolates was said to be only 2 embryo passages higher than the original seed virus. Included in the study, also for comparison, was a cell-culture-adapted 2512-cloned attenuated virus. Changes that may occur in the identity of a virus from manipulation, mutation, storage, errors in labeling or other factors are discussed. These characteristics should be identified if the virus is to be used as a vaccine, in research or for other purposes. The need for well-characterized reference strains in repositories is discussed relative to their importance in potential vaccine research and development.

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