HEMOPHILIA. I. THE ABNORMAL COAGULATION OF THE BLOOD AND ITS RELATION TO THE BLOOD PLATELETS

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Abstract
The identification of a substance or substances contained in normal blood which may supply a clotting factor deficient in hemophilic blood has been the aim of these observations. The procedure consisted of adding to hemophilic blood, both in vitro and in vivo, graded amounts of normal blood and certain of its separate components. In normal blood and in citrated normal plasma rendered free from platelets by Berkefeld filtration, there is a substance which in small quantity effectively reduces the clotting time of hemophilic blood. This substance is either greatly diminished or unavailable in hemophilic blood and plasma. It is stable for at least 2 months at 5-10[degree]C. Studies made with normal and hemophilic platelet suspensions in physiological concn. revealed no differences in their behavior regarding clot production.

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