Aberrant Heterozygotes in Escherichia Coli

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Abstract
Unstable prototrophs have been isolated from certain crosses in E. coli K-12, and characterized as segregating heterozygous diploids. The capacity to produce appreciable numbers of persistent heterozygous diploids is inherited. The segregation of various mutant factors is strongly biased, possibly due to recessive lethal deletion including a locus affecting maltose fermentation. In the heterozygotes, the type + alleles of factors controlling several fermentations and nutritional requirements are dominant. Sensitivity to bacterio-phage Tl is dominant to resistance.