Regulation and role of different macrophage- and granulocyte-inducing proteins in normal and leukemic myeloid cells

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Abstract
It has previously been shown that there are different molecular forms of macrophage- and granulocyte-inducing (MGI) proteins; one form, MGI-I, induced the formation of colonies with differentiated cells from normal myeloblasts and another form, MGI-2, induced normal differentiation in MGI+D+ leukemic myeloblasts that no longer require MGI-I to form colonies. The present results indicate that MGI-2 can also induce differentiation (without inducing colony formation) in the normal cells, and that MGI-I induced MIG-2 in the normal but not in the leukemic cells. It is suggested from these results that MGI-2 is the differentiation-inducing protein for normal and leukemic cells whereas MGI-I is the growth-inducing protein that induces colony formation by the normal cells, and that induction of differentiation in the normal cell colonies is due to induction of MGI-2 by MGI-I.

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