Zinc 65 metabolism: gastrointestinal secretion by the pig

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Abstract
The major fraction (96%) of a single intravenous injection of Zn65 was execreted by the pig with a 1/2-time of 100 days, the remainder with a 1/2-time of near 3 days. Fecal excretion accounted for 75-90% of the total Zn65 excreted. Ligation of the pancreatic duct and total fistulas of the pancreas and gall bladder, or of a 40-cm segment of duodenum did not reduce fecal excretion of Zn65 appreciably. A total 4-day collection of pancreatic juice and bile and a 5-day collection of duodenal juice accounted for 0. 475, 0.055, and 0.150%, respectively, of the injected Zn65. These values are approximately 10% of those reported from dog studies and this difference is discussed. The secretion of Zn65 in pancreatic juice was closely associated with total protein secretion. A specific pancreatic secretory cycle for Zn secretion is suggested. The behavior of Zn65 in blood fractions was observed and found to be similar to that of other species.