Effects of Cortisone in Tumor Transplantation2

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Abstract
In these studies, the observations of earlier workers that pretreatment with cortisone effectively aids in the growth of transplanted Sarcoma 180, Krebs-2, and Ehrlich ascites tumor cells have been confirmed. In a series of experiments, we made the following observations: If a minimally effective dose of cortisone was used, it had to be given before cell inoculation. With the use of cortisone, single Ehrlich cells could be consistently grown in subcutaneous tissues. Pretreatment with cortisone reduced the number of intravenously injected tumor cells required for the establishment of comparable numbers of tumor implants from approximately 2 million to only 5,000. The predominant site of metastases shifted from the lung in normal mice to the liver in cortisone-treated animals.