Anticonvulsants and the metabolism of separated mammalian cerebral tissues

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Abstract
The anticonvulsants diphenylhydantoin, methylethylphenylhydantoin, and trimethyloxazoli-dinedione were examined for possible effects on several metabolic characteristics of separated cerebral cortex from the guinea pig and rat. They were without effect on various aspects of glutamic acid metabolism and on the respiration of the tissues as ordinarily examined with several substrates. They wholly or partly prevented the increase in respiration of cerebral tissues caused by sinewave alternating currents of 2000 cps, or by brief condenser pulses. They had no effect on comparable increase in respiration brought about by 50 cps a.c, by 50 m[image] KC1, by 2:4-dinitrophenol, by guanidine or by a deca-methylenediguanidine. Respiratory inhibition by the anticonvulsants was comparable when glucose, lactate, or pyruvate was used as substrate. It was not shown by some compounds structurally related to the drugs but without anticonvulsant action. Changes in glycolysis, creatine phosphate and inorganic phosphate which accompanied the respiratory increase susceptible to the anticonvulsants were nevertheless unaffected by them. Anaerobic glycolysis was also unaffected by the anticonvulsants, until its level was altered by currents of 2000 cps. It then became susceptible; at 50 cps no action of the drugs was seen.